Deutsch

M1: Preclinical evaluation of a vaccine strategy based on conserved conformational epitopes of the HIV envelope glycoprotein

Dokumentation 1997–2006

Projektleiter:
Prof.Dr.Valerie Bosch

DKFZ, Tumorvirologie F 0200
Im Neuenheimer Feld 242
69120 Heidelberg

Projekttitel:

Preclinical evaluation of a vaccine strategy based on conserved conformational epitopes of the HIV envelope glycoprotein

Projektdauer:

01/2002 - 07/2007

Veröffentlichungen:
  • Denise Holtkotte, Tanya Pfeiffer, Thorsten Pisch and Valerie Bosch
    Selection and Characterization of a Replication-Competent Human Immunodeficiency Virus Type 1 Variant
    Encoding C-Terminally Truncated Env
    AIDS Research and Human Retroviruses, Vol. 22, Number 1, 2006, pp. 57-65
  • Tanya Pfeiffer, Thorsten Pisch, Gerard Devitt, Denise Holtkotte, Valerie Bosch
    Effects of signal peptide exchange on HIV-1 glycoprotein expression and viral infectivity in mammalian cells
    FEBS Letters 580 (2006) 3775-3778
  • Gerard Devitt, Vanessa Emerson, Thorsten Pisch, Oliver T. Keppler, Valerie Bosch
    Analysis of the exposure of induced HIV glycoprotein epitopes in a potential HIV pseudovirion vaccine
    Vaccine 25 (2007) 2161 - 2167
  • Gerard Devitt, Vanessa Emerson, Denise Holtkotte, Tanya Pfeiffer, Thorsten Pisch, Valerie Bosch
    Incorporation of chimeric HIV-SIV-Env and modified HIV-Env proteins into HIV pseudovirions
    Virology 361 (2007) 465 - 471
  • Gerard Devitt, Mini Thomas, Alexander M. Klibanov, Tanya Pfeiffer, Valerie Bosch
    Optimized protocol for the large scale production of HIV pseudovirions by transient transfection of HEK293T cells with linear fully deacylated polyethylenimine
    Journal of Virological Methods 2007
  • Valerie Bosch, Tanya Pfeiffer, Gerard Devitt, Ina Allespach, Thomas Ebensen, Vanessa Emerson, Carlos A. Guzman, Oliver T. Keppler
    HIV pseudovirion vaccine exposing EBv “fusion intermediates” – Response to immunisation in human CD4/CCR5-transgenic rats
    Vaccine 27 (2009) 2202-2212