M27.2: Entwicklung neuer gentechnischer Therapiemethoden für das solide Blasenkarzinom mit Antisense-Oligonukleotid-Cytostatika Kombinationen und Antisense-Oligonukleotid-Arzneistoff-Konjugaten
Dokumentation 1997–2006
Projektleiter:
Prof. Dr. med. M.S. Michel
Urologische Klinik
Universitätsklinikum Mannheim
Theodor-Kutzer-Ufer 1 - 3
68135 Mannheim
Projekttitel:
Entwicklung neuer gentechnischer Therapiemethoden für das solide Blasenkarzinom mit Antisense-Oligonukleotid-Cytostatika Kombinationen und Antisense-Oligonukleotid-Arzneistoff- Konjugaten
Projektdauer:
1/2004 - 1/2007
Veröffentlichungen:
- Bolenz C, Ikinger EM, Ströbel P, Trojan L, Steidler A, Fernández MI, Honeck P, Gabriel U, Weiss C, Grobholz R, Alken P, Michel MS
Topical Chemotherapy in Human Urothelial Carcinoma Explants: A Novel Translational Tool for Preclinical Evaluation of Experimental Intravesical Therapies.
Eur Uro. 2008 Jul. 30 - Bolenz C, Weiss Vm Wenzel M, Gabriel U, Steidler A, Becker A, Hermann E, Trojan L, Michel MS
In vivo evaluation of intravesical paclitaxel and combined bcl-xL antisense oligodeoxynucleotide treatment for orthotopic urothelial carcinoma
J Cancer Res Clin Oncol 2009 May; 135(5):679-86. Epub 2008 Oct 22 - Gabriel U, Bolenz C, Becker A, Schaaf A, Steidler A, Trojan L, Weiss C, Michel MS
Evaluation of cytotixic effects induced by bcl-2 and bcl.xL antisense oligodeoxynucleotides in normal urothelium and transitional cell carcinoma
Oncol Rep. 2008 Dec; 20 (6):1419-23 - Axel Schaaf, Sreedhar Sagi, Sigrun Langbein, M. D., Lutz Trojan, M. D., Peter Alken M. D., Maurice Stephan Michel, M. D.
Cytotoxicity of cisplatin in bladder cancer is significantly enhanced by application of bcl-2 antisense oligonucleotides
Urologie Oncology (2004) 188-192 - Christian Bolenz, Melanie Wenzel, Yanwei Cao, Lutz Trojan, Axel Häcker, Mario Fernandez Arancibia, Peter Alken, Maurice Stephan Michel
A newly developed mini-endoscope for diagnosis and follow-up of orthotopic bladder transitional cell carcinoma in the rat
Journal of Endourology (2006) - Christian Bolenz M.D., Andreas Becker, Lutz Trojan M.D., M.Sc., Axel Schaaf M.D. Ph.D., Yanwei Cao M.D., Christel Weiss M.D., Peter Alken M.D. Ph.D., Maurice Stephan Michel M.D. Ph.D.
Optimizing chemotherapy for transitional cell carcinoma by application of bcl-2 and bcl-xL antisense oligodeoxynucleotides
Urologic Oncology (2007) - Christian Bolenz (MD), Lutz Trojan (MD, MSc), Patrick Honeck (MD), Ute Gabriel, Gunnar Wendt-Nordahl (MD), Axel Schaaf (PhD), Peter Alken (MD, PhD), Maurice Stephan Michel (MD, PhD)
Cellular uptake and ex vivo urothelial penetration by oligodeoxynucleotides for optimized treatment of transitional cell carcinoma
Analytical and Quantitative Cytology and Histology (2007)
M27.3: Entwicklung einer adoptiven Immuntherapie des Nierenzellkarzinoms durch HER-2/neu-spezifische T-Zellen
Projektleiter:
Prof. Dr. W. Hammerschmidt
GSF-Forschungszentrum München
Abteilung Genvektoren
Marchioninistraße 25
81377 München
Projekttitel:
Entwicklung einer adoptiven Immuntherapie des Nierenzellkarzinoms durch HER-2/neu-spezifische T-Zellen
Projektdauer:
06/2005 -01/2008
Veröffentlichungen:
- Martina Wiesner, Caroline Zentz, Markus H. Hammer, Mark Cobbold, Florian Kern, Hans-Jochem Kolb, Wolfgang Hammerschmidt, Reinhard Zeidler, Andreas Mossmannn
Selection of CMV-specific CD8+ and CD4+ T cells by mini-EBV-transformed B cell lines
Eur. J. Immunol. 2005. 35: 2110-2121 - E Hettich, A. Janz, R. Zeidler, D. Pich, E. Hellebrand, B. Weissflog, A Mossmann and W. Hammerschmidt
Genetic design of an optimized packaging cell line for gene vectors transducing human B cells
Gene Therapy (2006); 1-13 - Caroline Zentz, Martina Wiesner, Stephen Man, Bernhard Frankenberger, Barbara Wollenberg, Peter Hillemanns, Reinhard Zeidler, Wolfgang Hammerschmidt and Andreas Moosmann
Activated B Cells mediate efficient expansion of rare antigen-specific T cells
Human Immunology 68, 75-85 (2007) - Martina Wiesner, Caroline Zentz, Christine Mayr, Rainer Wimmer, Wolfgang Hammerschmidt, Reinhard Zeidler, Andreas Moosmann
Conditional Immortalization of Human Cells by CD40 Ligation
LPoS ONE, January 2008, Issue 1, e1464
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