M73: Evaluierung der Rolle von Interleukin-2 bei einer Langzeitinfusion des Anti-GD-2 Antikörpers ch14.18/CHO beim Neuroblastom
Dokumentation 2015–2019
Projektleiter:
Prof. Dr. med. H. N. Lode
Klinik und Poliklinik für Kinder- und Jugendmedizin
Pädiatrische Hämatologie und Onkologie
Universitäts-Medizin Greifswald
Ferdinand-Sauerbruch-Straße
17475 Greifswald
Projekttitel:
Evaluierung der Rolle von Interleukin-2 bei einer Langzeitinfusion des Anti-GD-2 Antikörpers ch14.18/CHO beim Neuroblastom
Projektdauer:
05/2015 – 05/2019
Veröffentlichungen:
- Nikolai Siebert, Christin Eger, Diana Seidel, Madlen Jüttner, Maxi Zumpe, Danilo Wegner, Silke Kietz, Karoline Ehlert, Gareth J. Veal, Werner Siegmund, Michael Weiss, Hans Loibner, Ruth Ladenstein & Holger N. Lode
Pharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2
MABS 2016, VOL.8, NO.3, 604-616 - Christin Eger, Nikolai Siebert, Diana Seidel, Maxi Zumpe, Madlen Jüttner, Sven Brandt, Hans-Peter Müller, Holger N. Lode
Generation and Characterization of a Human/Mouse Chimeric GD2-Mimicking Anti-Idiotype Antibody Ganglidiximab for Active Immunotherapy against Neuroblastoma
PLOS ONE, DOI:10.1371/journal.pone.0150479, March 11,2016 - Kiraz Ceylan, Luciana J. Jahns, Bjoern N. Lode, Karoline Ehlert, Silke Kietz, Sascha Troschke-Meurer, Nikolai Siebert, Holger N. Lode Inflammatory response and treatment tolerance of long-term infusion of the anti-GD2 antibody ch14.18/CHO in combination with interleukin-2 in patients with high-risk neuroblastoma Pediatr Blood Cancer 2018;65:e26967 DOI:10.1002/pbc.26967
- Nikolai Siebert, Maxi Zumpe, Madlen Jüttner, Sascha Troschke-Meurer and Holger N. Lode PD-1 blockade augments anti-neuroblastoma immune response induced by anti-GD2 antibody ch14.18/CHO ONCOIMMUNOLOGY 2017, VOL.0, e1343775 https://doi.org/10.1080/2162402X.2017.1343775
- Ina Mueller, Karoline Ehlert, Stefanie Endres, Lena pill, Nikolai Siebert, Silke Kietz, Penelope Brock, Alberto Garaventa, Dominique Valteau-Couanet, Evelyne Janzek, Norbert Hosten, Andreas Zinke, Winfried Barthlen, Emine Varol, Hans Loibner, Ruth Ladenstein and Holger N. Lode Tolerability response and outcome of high-risk neuroblastoma patients treated with long-term infusion of anti-GD2 antibody ch14.18/CHO MABS 2018, VOL.10,NO.1,55-61 https://doi.org/10.1080/19420862.2017.1402997
- Low CD4+/CD25+/CD127- regulatory T cell- nd high INF-ylevels are assiciated with improved survival of neuroblastoma patients treated with long-term infusion of ch14.18/CHO combined with interleukin-2
Sascha Troschke Meurer, Nikolai Siebert, Madlen Marx, Maxi Zumpe, Karoline Ehlert, Oliver Mutschlechner, Hans Loibner, Ruth Ladenstein and
Oncoimmunology 2019, VOL.8, NO.12, e1661194
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